Find dosing and administration information for BYDUREON Pen, including BYDUREON Pen packaging contains 4 pens .. BYDUREON [package insert]. Learn about BYDUREON® BCiseTM including efficacy, safety, PK profile, and dosing, and available resources, including Important Safety Information. Package Leaflet: Information for the user. Bydureon 2 mg powder and solvent for prolonged-release suspension for injection in pre-filled pen exenatide. Read all.
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Extended-release exenatide is not a first-line therapy for patients inadequately controlled on diet and exercise. The Cmax values increased less than proportionally over the same range. Help me understand type bydureno diabetes better.
Based on animal reproduction studies, there may be risks to the fetus from exposure to exenatide during pregnancy, therefore, exenatide should only be used during pregnancy if the potential benefit justifies the potential risk to the fetus. Diabetes medication pens should packagd be shared among patients. Exenatide regular-release injection solution Byetta: Pegvisomant increases sensitivity to insulin by lowering the activity of growth hormone, and in some patients glucose tolerance improves with treatment.
Moderate Disturbances of blood glucose, including hyperglycemia and hypoglycemia, have been reported in patients treated concomitantly with quinolones and an antidiabetic agent.
Combined use with prandial insulin has not been studied and cannot be recommended. Angiotensin II receptor antagonists: Ensure the medicine is mixed evenly; rotate and shake or tap as directed until there is no white medicine visible on sides of the pen or syringe. Other oral hypoglycemics may also be considered as possible alternatives in some patients. Moderate Changes in insulin sensitivity or glycemic control may occur in patients treated with androgens. First-phase insulin response release of insulin within 10 minutes following a glucose load is lost in patients with type 2 diabetes.
Moderate Thiazide diuretics can decrease insulin sensitivity thereby leading to glucose intolerance and hyperglycemia. Inject over 2 to 4 seconds. Recommendations will be communicated once the review is complete; continue to consider precautions related to pancreatic risk until more data are available. Moderate Sympathomimetic agents and adrenergic agonists tend to increase blood glucose concentrations when administered systemically.
Patients receiving incretin mimetics should be closely monitored for changes in glycemic control. Because of this, a potential pharmacodynamic interaction exists between these drugs and all antidiabetic agents, including incretin mimetics. Hyperglycemia and glycosuria have been reported. Patients who are taking antidiabetic agents should monitor for worsening glycemic control when a phenothiazine is instituted. Taking an oral contraceptive OC at least 1 hour before an incretin mimetic injection should reduce the risk of an effect on contraceptive or hormonal absorption.
Other reviews suggest that garlic may provide modest improvements in blood lipids, but few studies demonstrate decreases in blood glucose in diabetic and non-diabetic patients. Epinephrine and other sympathomimetics, through stimulation of alpha- and beta- receptors, increase hepatic glucose production and glycogenolysis and inhibit insulin secretion.
Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine: Do NOT mix exenatide with insulin. An insulin glargine dose titration algorithm is in the exenatide package insert.
Selective beta-blockers, such as atenolol or metoprolol, do not appear to potentiate insulin-induced hypoglycemia. Double-check dosage prior to administration.
Push the autoinjector against the skin at the chosen injection site. Moderate The risk of hypoglycemia is increased when exenatide is used in combination with insulins.
Alternatively, administer before the 2 main meals of the day, with the doses approximately 6 hours or more apart. Also, while the manufacturers of metformin recommend against breast-feeding while taking the drug, metformin may be a possible alternative for some patients.
If exenatide is discontinued and blood glucose is not controlled on insett and exercise alone, insulin therapy should be considered. Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide: Furthermore, tacrolimus has been implicated in causing insulin-dependent diabetes mellitus in patients after renal transplantation.
Recipient’s Email Separate multiple email address with a comma Please enter valid email address Recipient’s email is required. In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, may decrease antidiabetic agent dosage requirements. In patients with type 2 diabetes, exenatide moderates glucagon secretion and lowers serum glucagon concentrations during periods of hyperglycemia. The following pen needles have been tested and are considered to be compatible with the Byetta pre-filled pen: The mechanism of the interaction is not known although it may be due to delayed gastric emptyingnor is the clinical significance of this potential interaction.
No dosage adjustment needed.